John Snow, M.D.: Early Career
John Snow: "Autotype from a presentation portrait, 1856,
and autograph facsimile." Credit for both image and caption, Wellcome
Library, London.
Little wonder that John Snow (1813-1858), the doctor who
discovered how cholera was transmitted and thrust his findings in the
face of a disbelieving medical establishment, should have become one of
the heroes of medical science. A farmer's son from the north, who
trekked all the way to the great metropolis to (eventually) become its
saviour, his story is the very stuff of legend. Even by today's more
measured assessment, he remains a towering figure, especially in the
fields of epidemiology and public health.
Born in York, John Snow was the son of a Yorkshire labourer who later
became a relatively well-to-do farmer. The youth was apprenticed at
fourteen to an enlightened and well-connected Newcastle surgeon, William
Hardcastle, who was on the staff of Newcastle's Lying-In Hospital.
He first came up against cholera when it swept through the nearby West
Moor colliery, a few miles from town by the village of Killingworth.
This was during the epidemic of 1831-32. But at the time when cholera
broke out again in 1846 Snow was in London. Having travelled to London
on foot in 1836, Snow had now completed not just his apprenticeship but a
thorough all-round training, including surgical practice at Westminster
Hospital. In 1838 he had moved to Soho, opening a practice in Frith
Street there, and also attending out-patients at Charing Cross Hospital,
only a short distance away. He had subsequently earned medical degrees
at the University of London (now University College, London), which had its medical facilities at University College Hospital.
In 1845 he had become a lecturer in forensic medicine at the
short-lived Aldersgate School of Medicine — though a large part of his
experience had been in obstetrics, and his early interest was in the
resuscitation of still-born infants, he also had a specialised knowledge
of lead poisoning. Besides, in whatever he had undertaken, he had
proved himself a keen and cutting-edge investigator. By the late 1840s
he was best known for his research into anaesthesia, having published a
groundbreaking study, On the Inhalation of the Vapour of Ether in Surgical Operations, in 1848.Dr Snow's Early Investigations into Cholera
Snow had been a high-minded young man, a vegetarian as
well as a teetotaller. In his more mature years, he was still a man of
integrity, evincing "a complete lack of acquisitiveness and personal
ambition" (Hempel 106). A bachelor, he was wedded to his work, endlessly
painstaking in it, and dedicated to his scientific and humanitarian
pursuits. On the theoretical level, he had approached the subject of
anaesthetics from many different angles, from looking at the properties
of the gas itself to studying its physiological and psychological
effects. He had followed his findings right through to the practical
stage as well, working out and designing the best means of
administration. He had tested his inhalers in animal experiments, and
had not shrunk from testing them on himself (see Johnson 65-68). Armed
with his understanding of the operation of gases, when he again found
himself treating cholera cases in his neighbourhood, he was not inclined
simply to accept the prevailing "miasmic" orthodoxy.
Moreover, he was prepared to follow unusual routes to establish his own
theory. These ranged from reading accounts of the previous epidemic and
examining current cases to consulting chemists, water suppliers and
sewer authorities (see Johnson 71-74). By these means he worked out to
his own satisfaction that the disease was spread not by touch, not
through the air, but by ingestion. As he himself put it: "The morbid
material producing cholera must be introduced into the alimentary canal —
must in fact be swallowed accidentally, for persons would not take it
intentionally" (Snow, On the Mode of Communication, 15).
Left: "Monster Soup, being a correct representation of
that precious stuff doled out to us." A coloured etching by William
Heath (1795-1840), 1828. Credit: Wellcome Library, London. Microscopic
demonstrations had become popular at this time, but a woman drops her
cup of tea in horror when she realises what Thames water might contain.
Ironically for the present subject, a tiny figure in the left-hand
corner doffs his hat to a water pump, supposedly a source of cleaner
water. Right: A Punch illustration, in an article of 1850
entitled "The Water Kings," shows a boy shrinking away from the glass of
water offered by Old Father Thames, who has his other hand on a tap
(Vol. 18, p.62).
In an overcrowded city, with only the most primitive provisions for
disposing of human waste, the finger pointed at contaminated water. In
1849 Snow published what should have been another groundbreaking paper, On the Mode of Communication of Cholera,
demonstrating that more people died from cholera in the area served by
certain South London water companies. These drew their water straight
from the River Thames, which, at this time, had around sixty sewage
outlets gushing into it (White 51).The Reception of Dr Snow's Theory
Everyone knew the disgusting state of the Thames.
Chadwick's insistence on removing human waste from cellars, and running
it into the current drainage system, had only made it worse, as had the
growing popularity of water closets. However, Snow's paper failed to
make as much impression as the smell of the river itself. Another
doctor, who still favoured the widely-held miasmic theory of
contaminated air, wrote in the same year,
That cholera is produced by a specific poison is generally
admitted by writers upon the subject. As to the essential nature of
this specific miasm we are entirely ignorant; and we do not think it
would serve any useful purpose to enter into a discussion upon the
various hypotheses which have been proposed. For the most part the
explanation offered to account for the mode of action of any one miasm
will not cover the whole question; and this, in our opinion, is a fatal
objection, for it is obvious that they present but one problem; and the
true solution, when it comes, will explain all the varieties of the
phenomenon. (Russell 122)
Others discussed Snow's hypothesis but mistrusted it: "At
present these opinions of Dr Snow's can be considered only ingenious
speculation," said one (Bushnan 33).
The Broad Street Pump
Left to right: (a) John Snow's house in Sackville Street,
off Piccadilly (since demolished), with a plaque describing him as
"physician and specialist anaesthetist who discovered that cholera is
water-borne." (b) Snow's map of the area that provided the best evidence
for his theory, around the Broad Street pump. Broad (now Broadwick)
Street, W1, is the street that runs diagonally across the middle. Here,
the black bars merge to denote houses where people died of the disease.
These stand alongside the pump on the corner with Cambridge Street (now
Lexington Street). (c) Silhouette of the pump indicating its original
location. A replica has now been placed nearby. Credit for all three
images: Wellcome Library, London.
Snow, who was nothing if not tenacious, now set out to
provide precise evidence in support of his theory. This time, supported
by another local doctor and vestryman Edwin Lankester, and at
street-level by local clergyman Henry Whitehead, he focused his
investigation on the Broad Street area of Soho. Using statistics
acquired from the General Register Office, he was able to demonstrate
graphically that an unusual number of the 1853-54 fatalities had
occurred among those drinking water from the pump there. The map on
which he charted these fatalities was not the first to highlight
clusters of a disease. But, after showing it to the Epidemiological
Society in December 1854, he made a significant modification. Around the
black bars representing the houses where deaths had occurred, he drew a
line indicating closeness by foot to the pump. The uneven line,
following the street pattern, made it clear that this was not a case of
simply breathing in the air around the pump. He was also able to
demonstrate that those who lived nearby, but drank from different
sources (such as the local brewery's pipeline), had been spared.
Finally, Whitehead did him a signal service by helping uncover the
original source of the contamination: from talking to a bereft mother,
he learnt that contaminated water had been thrown into a nearby
cesspool. This proved to have leaked its virulent contents into the
water source. As Lankester would say later, "the evidence adduced [in
the revised monograph pf 1855] was most circumstantial and conclusive" . Though the epidemic was dying out by then, the parish Board of
Guardians agreed to remove the pump handle so that people could no
longer use it.
Reception of the Revised Edition of Dr Snow's Monograph
Snow seemed to have presented an open and shut case for
his theory that the dreaded disease was passed on, as he was now able to
formulate it, by the mixture of cholera evacuations with the water used
for drinking and culinary purposes, either by permeating the ground, or
getting into wells, or by running along channels and sewers into the
rivers from which entire towns are sometimes supplied with water.
Whitehead had certainly been convinced, Lankester perhaps
less so at that time. But at any rate the Board of Guardians had acted
on Snow's findings. In the eyes of the medical establishment, however,
the jury was still out. "This mode of conveyance was so novel that when
first suggested it was almost universally opposed," said Lankester,
adding "not a member of his own profession, not an individual in the
parish believed that Dr Snow was right" (30-31; 34-35). Opponents of
the theory continued to insist that there were other outbreaks that it
failed to cover. They still preferred to blame "the atmosphere or its
concomitant imponderable agents" (Acland 77). The Lancet
criticised Snow savagely in its issue of 26 June 1858: "The fact is,
that the well whence Dr Snow draws all sanitary truth is the main sewer.
His secus, or den, is a drain" (qtd. in Johnson 205). Even in
1861, Mrs Beeton's specifics against cholera were "cleanliness,
sobriety and judicious ventilation" (1073), not clean drinking water.
Florence Nightingale, who nursed so many cases of the disease in the
Crimea, remained a "convinced miasmatist" all her long life.
John Tenniel's famous cartoon, in the Punch
of 10 June 1858 (facing p.17), shows a skeleton rowing along the
Thames, with dead creatures floating alongside, and St Paul's, beloved
symbol of the city and its spiritual life, in the distance. The Thames
was still "a river of death" at this time, and the remedy involved a
heavy financial commitment — hence the sub-caption, "Your MONEY or your
LIFE!"
However, once he was thoroughly convinced, Lankester became a
formidable ally to the cause. Appointed the first medical officer of
health for Westminster in 1856, he was "a born publicist, teacher and
reformer" (English). When The Lancet finally
came round in 1866, it heaped praise on Snow as a "great public
benefactor" who had "enabled us to meet and combat the disease" (qtd. in
Johnson 213). At this time too, the last outbreak of cholera convinced
William Farr, the superintendent of statistics at the General Register
Office, that Snow had been right, and that water was, if not the only,
then at least the most important, vehicle of the infection: he found
that almost all those recently affected were getting their water from a
part of the river not yet properly served by Joseph (later Sir Joseph) Bazalgette's
new sewerage system. Though Farr never quite gave up his own belief
that environmental factors were involved as well (see Eyler 230), this
allowed social science to align itself more securely with Snow's
detective work.The Italian anatomist Filippo Pacini had already discovered the agent that caused cholera by then. When Robert Koch isolated it in 1883, and gained publicity for his findings, the last piece of the puzzle fell into place. Vibrio cholerae thrives in an aquatic environment — and inside human intestines. The accuracy of Snow's finding, and its full implications, could now be properly appreciated.
Dr Snow's Death and Reputation
Left: Equipment for the use of ether as an anaesthetic.
Credit: Wellcome Library, London. Snow's pioneering work in this area
was more widely recognised in his own lifetime. Right: Snow's grave in
Brompton Cemetery,
with a replica headstone replacing the one that was destroyed in an
air-raid during the last World War (photograph by the present author).
In his final decade, Snow achieved eminence as an anaesthetist, attending Queen Victoria
in her last two childbirths, in 1853 and 1857. On the first occasion,
he and his colleagues had been criticised in the ever-sceptical Lancet
(see "Anesthesia and the Queen"), but by the second, the queen's own
endorsement had made the practice acceptable. However, Snow had a stroke
in the following year, while preparing his latest work, On Chloroform and Other Anaesthetics
(1858), for publication. He was found to have had underlying health
problems, which his experiments on himself, not to mention the
opposition to his ideas about cholera, might well have exacerbated.
Nevertheless, John Snow is still a very important figure in the history of epidemiology. The Broad Street episode is seen, appropriately enough, as a "watershed event," significant not simply because it proved Edwin Chadwick and the many other miasmatists to be wrong, but also because it showed that an epidemic could be tackled by practical intervention. It marks "the first time in history when a reasonable person might have surveyed the state of urban life and come to the conclusion that cities would someday become great conquerors of disease" (Johnson 235). The fact that hardly any "reasonable person" did appreciate this at the time is an important part of the story — the story of one man's doggged search for an answer, and persistence in trying to convince others that he had found it. This story has a life of its own outside the annals of medical science. Snow's greatest achievement may be in encouraging us to confront the problems that face the world today, and to have the courage of our own convictions, so that we too can help secure a viable way of life for future generations.
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